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Citric acid, potassium citrate, and sodium citrate and Renal dysfunction

Result of checking the interaction of drug Citric acid, potassium citrate, and sodium citrate and disease Renal dysfunction for safety when used together.

Check result:

Citric acid, potassium citrate, and sodium citrate <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of potassium salts is contraindicated in patients with severe renal impairment characterized by oliguria, anuria, or azotemia. Since potassium is excreted by the kidney, the administration of potassium salts in such patients, particularly by the intravenous route, may produce hyperkalemia and cardiac arrhythmias or arrest. Therapy with potassium salts should be administered cautiously in patients with diminished renal function or other conditions which impairs potassium excretion (e.g. adrenal insufficiency). Close monitoring of serum potassium concentrations is recommended, as potentially fatal hyperkalemia can develop rapidly and is often asymptomatic, manifested only by an increased potassium level (6.5 to 8 mEq/L) and characteristic electrocardiographic changes (peaking of T waves, loss of P waves, depression of ST segment, prolongation of the QT interval). Late manifestations include muscle paralysis and cardiovascular collapse from cardiac arrest (9 to 12 mEq/L). Continuous or serial electrocardiography may be appropriate in some patients during replacement therapy, particularly if given intravenously.

References:

"Product Information. Urocit (potassium citrate)." Mission Pharmacal Company, San Antonio, TX.
"Product Information. K-Dur (potassium chloride)." Schering Laboratories, Kenilworth, NJ.
"Product Information. Kaon (potassium gluconate)." Savage Laboratories, Melville, NY.
"Product Information. Potassium Acetate (potassium acetate)." Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. K-Lyte (potassium bicarbonate-potassium citrate)." Bristol-Myers Squibb, Princeton, NJ.

Citric acid, potassium citrate, and sodium citrate

Generic Name: citric acid / potassium citrate / sodium citrate

Brand Name: Cytra-3, Polycitra, Polycitra-LC, Tricitrates, Virtrate-3

Synonyms: Citric Acid, Sodium Citrate, and Potassium Citrate

What is Citric acid, potassium citrate, and sodium citrate?