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Chlorpheniramine, Pseudoephedrine, and Dextromethorphan and Cardiovascular

Result of checking the interaction of drug Chlorpheniramine, Pseudoephedrine, and Dextromethorphan and disease Cardiovascular for safety when used together.

Check result:

Chlorpheniramine, Pseudoephedrine, and Dextromethorphan <> Cardiovascular

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Antihistamines may infrequently cause cardiovascular adverse effects related to their anticholinergic and local anesthetic (quinidine-like) activities. Tachycardia, palpitation, ECG changes, arrhythmias, hypotension, and hypertension have been reported. Although these effects are uncommon and usually limited to overdosage situations, the manufacturers and some clinicians recommend that therapy with antihistamines be administered cautiously in patients with cardiovascular disease, hypertension, and/or hyperthyroidism.

References:

"Product Information. Dimetane (brompheniramine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Chlortrimeton (chlorpheniramine)." Schering-Plough, Liberty Corner, NJ.
"Product Information. Optimine (azatadine)." Schering Laboratories, Kenilworth, NJ.
"Product Information. Antivert (meclizine)." Roerig Division, New York, NY.
"Product Information. Tavist (clemastine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
"Product Information. Periactin (cyproheptadine)." Merck & Co, Inc, West Point, PA.
Smith SJ "Cardiovascular toxicity of antihistamines." Otolaryngol Head Neck Surg 111 Suppl (1994): 348-54
"Product Information. Zyrtec (cetirizine)." Pfizer US Pharmaceuticals, New York, NY.
"Product Information. Drixoral (dextromethorphan)." Schering-Plough, Liberty Corner, NJ.
Schuller DE, Turkewitz D "Adverse effects of antihistamines." Postgrad Med 79 (1986): 75-86
Woosley RL "Cardiac actions of antihistamines." Annu Rev Pharmacol Toxicol 36 (1996): 233-52
"Product Information. Benadryl (diphenhydramine)." Parke-Davis, Morris Plains, NJ.
"Product Information. Dramamine (dimenhydrinate)" Pharmacia and Upjohn, Kalamazoo, MI.
"Product Information. Poly-Histine-D (pyrilamine)." Bock Pharmaceutical Company, St. Louis, MO.
"Product Information. Vistaril (hydroxyzine)." Pfizer US Pharmaceuticals, New York, NY.

Chlorpheniramine, Pseudoephedrine, and Dextromethorphan

Generic Name: chlorpheniramine / dextromethorphan / pseudoephedrine

Brand Name: Kidkare Cough/Cold, Pediatric Cough & Cold Medicine, Rescon-DM, Triaminic Cold and Cough, Vicks Pediatric Formula 44M, Triaminic Night Time, Rhinosyn-DM, Pediacare Nightrest, Pediacare Cough-Cold Chewable, Robitussin Pediatric Night Relief, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Nyquil Child Cough and Cold, Creomulsion Pediatric, Pediacare Cough and Cold, Childrens Night Time, Children's NyQuil, Triaminic Softchew Cold and Cough, Tanafed-DM, C-Phed DM, T-Tanna-DM, M-End DM, Atuss-12 DM, Robitussin PM Cough & Cold, Dicel DM, Atuss DS, Neutrahist PDX Drops, AccuHist PDX Drops, Triaminic Multi-Sympton, Allres DS, Triaminic-D Multi-Symptom Cold, Entre-S, Dicel DM Chewables, Mesehist DM, Esocor P, Kidkare Children's Cough/Cold, Maxichlor PSE DM, Pedia Relief Cough-Cold, Pediatric Cough & Cold, Rescon DM

Synonyms: Chlorpheniramine, dextromethorphan, and pseudoephedrine

What is Chlorpheniramine, Pseudoephedrine, and Dextromethorphan?