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Chloroquine and Ototoxicity

Result of checking the interaction of drug Chloroquine and disease Ototoxicity for safety when used together.

Check result:

Chloroquine <> Ototoxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of 4-aminoquinolines has been associated rarely with ototoxicity. Nerve-type deafness, which is usually irreversible, has occurred during long-term, high-dose therapy. Deafness may not be apparent until several weeks after 4-aminoquinoline therapy. Tinnitus and reduced hearing have been reported in patients with preexisting auditory damage. Therapy with 4-aminoquinolines should be administered cautiously in such patients. If new auditory defects develop or if hearing loss becomes worse, therapy should be immediately discontinued and the patient closely monitored.

References:

"Product Information. Plaquenil (R). (hydroxychloroquine)." Sanofi Winthrop Pharmaceuticals, New York, NY.
"Product Information. Aralen (chloroquine)." Sanofi Winthrop Pharmaceuticals, New York, NY.

Chloroquine

Generic Name: chloroquine

Brand Name: Aralen Phosphate, Aralen Hydrochloride

Synonyms: n.a.

What is Chloroquine?