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Chloroquine and Hepatotoxicity

Result of checking the interaction of drug Chloroquine and disease Hepatotoxicity for safety when used together.

Check result:

Chloroquine <> Hepatotoxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Aminoquinolines may concentrate in the liver. Isolated cases of abnormal liver function and fulminant hepatic failure have been reported. Therapy with aminoquinolines should be administered cautiously in patients with hepatic disease or alcoholism and in patients receiving other hepatotoxic drugs. Periodic evaluation of hepatic function should be performed during prolonged therapy.

References:

Liu AC "Hepatotoxic reaction to chloroquine phosphate in a patient with previously unrecognized porphyria cutanea tarda." West J Med 162 (1995): 548-51
Grossman I, Azaz-Livshits T, Fridlender Z, Muszkat M, Ben-Chetrit E "Mefloquine-induced acute hepatitis." Pharmacotherapy 20 (2000): 1517-9
"Product Information. Aralen (chloroquine)." Sanofi Winthrop Pharmaceuticals, New York, NY.
"Product Information. Plaquenil (R). (hydroxychloroquine)." Sanofi Winthrop Pharmaceuticals, New York, NY.

Chloroquine

Generic Name: chloroquine

Brand Name: Aralen Phosphate, Aralen Hydrochloride

Synonyms: n.a.

What is Chloroquine?