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Chloroquine and Bone marrow suppression

Result of checking the interaction of drug Chloroquine and disease Bone marrow suppression for safety when used together.

Check result:

Chloroquine <> Bone marrow suppression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Adverse hematologic effects including neutropenia, agranulocytosis, aplastic anemia, and thrombocytopenia have been rarely associated with 4-aminoquinolines. Therapy with 4-aminoquinolines should be administered cautiously in patients with preexisting bone marrow suppression. A complete blood count should be performed periodically in patients on prolonged therapy. If any severe blood disorder appears which is not attributable to the disease under treatment, discontinuance of the drug should be considered.

References:

Winkelman RK, Merwin CF, Brunsting LA "Antimalarial therapy of lupus erythematosus." Ann Intern Med 55 (1961): 772-6
"Product Information. Aralen (chloroquine)." Sanofi Winthrop Pharmaceuticals, New York, NY.
"Product Information. Plaquenil (R). (hydroxychloroquine)." Sanofi Winthrop Pharmaceuticals, New York, NY.
Polano MK, Cats A, van Olden GAJ "Agranulocytosis following treatment with hydroxychloroquine sulphate." Lancet 1 (1965): 1275

Chloroquine

Generic Name: chloroquine

Brand Name: Aralen Phosphate, Aralen Hydrochloride

Synonyms: n.a.

What is Chloroquine?