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Cefditoren pivoxil and Carnitine deficiency

Generic Name: cefditoren
Dosage Forms: n.a.
Other Brand Names: Spectracef

Result of checking the interaction of drug Cefditoren pivoxil and disease Carnitine deficiency for safety when used together.

Check result:

Cefditoren pivoxil <> Carnitine deficiency

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of cefditoren pivoxil is contraindicated in patients with carnitine deficiency or congenital metabolic disorders that may result in clinically significant carnitine deficiency, since the drug can cause renal excretion of carnitine. Cefditoren pivoxil is hydrolyzed by esterases in vivo to cefditoren and pivalate, the latter of which is primarily eliminated (> 99%) through renal excretion as pivaloylcarnitine. In healthy volunteers given cefditoren pivoxil for 10 to 14 days, plasma carnitine concentrations decreased by an average of 39% to 63% depending on dosage and returned to the normal control range within 7 to 10 days after discontinuation of cefditoren pivoxil.

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