Drug search by name

Cardioquin and Liver dysfunction

Result of checking the interaction of drug Cardioquin and disease Liver dysfunction for safety when used together.

Check result:

Cardioquin <> Liver dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Quinidine is primarily metabolized by the liver to active and inactive forms. Hepatic dysfunction causes a slowed metabolism and elimination of the drug which can lead to quinidine toxicity if dosage is not appropriately reduced. Clinical monitoring of hepatic function is recommended.

References:

Affrime M, Reidenberg MM "The protein binding of some drugs in plasma from patients with alcoholic liver disease." Eur J Clin Pharmacol 8 (1975): 267-9
Handler SD, Hirsch NR, Haas K, Davidson FZ "Quinidine hepatitis." Arch Intern Med 135 (1975): 871-2
Debruyne D, Gram LF, Grollier G, et al "Quinidine disposition in relation to antipyrine elimination and debrisoquine phenotype in alcoholic patients with and without cirrhosis." Int J Clin Pharmacol Res 9 (1989): 319-25
Deisseroth A, Morganroth J, Winokur S "Quinidine-induced liver disease." Ann Intern Med 77 (1972): 595-7
Bramlet DA, Posalaky Z, Olson R "Granulomatous hepatitis as a manifestation of quinidine hypersensitivity." Arch Intern Med 140 (1980): 395-7
Hogan DB, Morin J, Crilly RG "Unusual hepatotoxic reaction to quinidine ." Can Med Assoc J 130 (1984): 973
Chajek T, Lehrer B, Geltner D, Levij IS "Quinidine-induced granulomatous hepatitis." Ann Intern Med 81 (1974): 774-6
"Product Information. Quinidex (quinidine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Herman JE, Bassan HM "Liver injury due to quinidine." JAMA 234 (1975): 310-11
Knobler H, Levij IS, Gavish D, Chajek-Shaul T "Quinidine-induced hepatitis: a common and reversible hypersensitivity reaction." Arch Intern Med 146 (1986): 526-8

Cardioquin

Generic Name: quinidine

Brand Name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Cardioquin?