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Acyclovir and hydrocortisone Topical application and Diabetes

Result of checking the interaction of drug Acyclovir and hydrocortisone Topical application and disease Diabetes for safety when used together.

Check result:

Acyclovir and hydrocortisone Topical application <> Diabetes

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Corticosteroids can raise blood glucose level by antagonizing the action and suppressing the secretion of insulin, which results in inhibition of peripheral glucose uptake and increased gluconeogenesis. Therapy with topical corticosteroids rarely produces these effects but should be administered cautiously nonetheless in patients with diabetes mellitus, glucose intolerance, or a predisposition to hyperglycemia. Systemic absorption of topical corticosteroids may occur depending on the vehicle and concentration of the preparation, the size of the application area, the integrity of the skin, and the duration of administration. Use of occlusive dressings over the applied areas may also increase percutaneous absorption. Given equivalent doses, small children are generally at the greatest risk because of their larger skin surface to body mass ratios. If possible, the use of highly potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol) should be avoided in children and limited to small areas for 2 weeks in adults.

References:

"Product Information. Cyclocort (amcinonide topical)." Fujisawa, Deerfield, IL.
"Product Information. Decadron Phosphate, Topical (dexamethasone topical)." Merck & Co, Inc, West Point, PA.
"Product Information. Cloderm (clocortolone topical)" Hermal Pharmaceutical Labs Inc, Delmar, NY.
"Product Information. Proctocream HC 2.5% (hydrocortisone topical)." Schwarz Pharma, Mequon, WI.
"Product Information. Dermatop (prednicarbate topical)." Janssen Pharmaceuticals, Titusville, NJ.
"Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc, Palo Alto, CA.
"Product Information. Aristocort Topical (triamcinolone topical)." Fujisawa, Deerfield, IL.
"Product Information. Lidex (fluocinonide)." Syntex Laboratories Inc, Palo Alto, CA.
"Product Information. Psorcon (diflorasone topical)." Rhone-Poulenc Rorer, Collegeville, PA.
"Product Information. Temovate (clobetasol)." Glaxo Wellcome, Research Triangle Park, NC.
Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
"Product Information. Halog (halcinonide)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Topicort (desoximetasone topical)." Hoechst Marioin-Roussel Inc, Kansas City, MO.
"Product Information. Aclovate (alclometasone topical)." Glaxo Wellcome, Research Triangle Pk, NC.
Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
"Product Information. Pandel (hydrocortisone topical)." Savage Laboratories, Melville, NY.
"Product Information. Elocon (mometasone topical)." Schering Corporation, Kenilworth, NJ.
"Product Information. Diprolene (betamethasone topical)." Schering Laboratories, Kenilworth, NJ.
"Product Information. Ultravate (halobetasol)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Kenalog (triamcinolone topical)." Westwood Squibb Pharmaceutical Corporation, Buffalo, NY.
"Product Information. Cordran (flurandrenolide topical)." Oclassen Pharmaceuticals Inc, Corona, CA.
"Product Information. Desowen (desonide topical)." Galderma Laboratories Inc, Fort Worth, TX.
"Product Information. Cutivate (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.