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Carbamazepine Extended-Release Capsules (Carbatrol) and Arrhythmias

Result of checking the interaction of drug Carbamazepine Extended-Release Capsules (Carbatrol) and disease Arrhythmias for safety when used together.

Check result:

Carbamazepine Extended-Release Capsules (Carbatrol) <> Arrhythmias

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Aromatic antiepileptic drugs (phenytoin, carbamazepine, oxcarbazepine, and lamotrigine) inhibit voltage- gated sodium channels and reduce membrane excitability in neurons and muscle and can be associated with cardiovascular effects. Individual agents have demonstrated AV heart block, including second and third-degree block following treatment. This occurred generally, but not solely in patients with underlying EKG abnormalities or risk factors for conduction abnormalities. Therapy with these agents should be considered and administered cautiously in patients with a history of cardiovascular disease and conduction abnormalities.

References:

Steckler TL "Lithium- and carbamazepine-associated sinus node dysfunction: nine-year experience in a psychiatric hospital." J Clin Psychopharmacol 14 (1994): 336-9
Boesen F, Andersen EB, Jensen EK, Ladefoged SD "Cardiac conduction disturbances during carbamazepine therapy." Acta Neurol Scand 68 (1983): 49-52
Kenneback G, Bergfeldt L, Vallin H, et al "Electrophysiologic effects and clinical hazards of carbamazepine treatment for neurologic disorders in patients with abnormalities of thecardiac conduction system." Am Heart J 121 (1991): 1421-9
Weig SG, Pollack P "Carbamazepine-induced heart block in a child with tuberous sclerosis and cardiac rhabdomyoma - implications for evaluation and follow-up." Ann Neurol 34 (1993): 617-9
"Product Information. Tegretol (carbamazepine)." Novartis Pharmaceuticals, East Hanover, NJ.
Isojarvi JI, Airaksinen KE, Repo M, Pakarinen AJ, Salmela P, Myllyla VV "Carbamazepine, serum thyroid hormones and myocardial function in epileptic patients." J Neurol Neurosurg Psychiatry 56 (1993): 710-2

Carbamazepine Extended-Release Capsules (Carbatrol)

Generic Name: carbamazepine

Brand Name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carbamazepine, CarBAMazepine

What is Carbamazepine Extended-Release Capsules (Carbatrol)?