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Actoplus Met XR and Weight gain

Result of checking the interaction of drug Actoplus Met XR and disease Weight gain for safety when used together.

Check result:

Actoplus Met XR <> Weight gain

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Thiazolidinediones can cause dose-related weight gain, which may be undesirable in obese patients attempting to lose weight. The mechanism of weight gain is unclear but probably involves a combination of fluid retention and fat accumulation. In postmarketing experience with rosiglitazone, there have been reports of unusually rapid increases in weight, greater than those generally observed in clinical trials. Patients who experience such increases should be assessed for fluid retention and volume-related events such as excessive edema and congestive heart failure.

References:

"Product Information. Avandia (rosiglitazone)" SmithKline Beecham, Philadelphia, PA.
"Product Information. Actos (pioglitazone)" Takeda Pharmaceuticals America, Lincolnshire, IL.

Actoplus Met XR

Generic Name: metformin / pioglitazone

Brand Name: Actoplus Met, Actoplus Met XR

Synonyms: n.a.

What is Actoplus Met XR?