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Caffeine and ergotamine oral/rectal and Liver disease

Generic Name: caffeine / ergotamine
Dosage Forms: n.a.
Other Brand Names: Cafergot, Migergot , Wigraine, Cafetrate, Ercaf, Cafatine

Result of checking the interaction of drug Caffeine and ergotamine oral/rectal and disease Liver disease for safety when used together.

Check result:

Caffeine and ergotamine oral/rectal <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

In general, CNS stimulants are extensively metabolized by the liver. Their plasma clearance may be decreased and their half-life prolonged in patients with impaired hepatic function. Therapy with CNS stimulants should be administered cautiously in patients with moderate to severe liver disease, and the dosage should be adjusted accordingly. Additionally, postmarketing reports have shown that atomoxetine can cause severe liver injury. Laboratory testing should be done at the first sign or symptom of liver dysfunction (jaundice, dark urine, upper quadrant tenderness) and treatment should be discontinued in patients with evidence of liver injury.

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