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Buspirone and Renal/liver disease

Result of checking the interaction of drug Buspirone and disease Renal/liver disease for safety when used together.

Check result:

Buspirone <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Buspirone is primarily metabolized by the liver and subsequently eliminated by the kidney. In one study, steady-state area under the plasma concentration-time curve (AUC) of buspirone increased 13-fold in subjects with hepatic impairment and 4-fold in those with renal impairment compared to healthy subjects. Therapy with buspirone is not recommended in the presence of significantly impaired hepatic or renal function.

References:

Dalhoff K, Poulsen HE, Garred P, et al "Buspirone pharmacokinetics in patients with cirrhosis." Br J Clin Pharmacol 24 (1987): 547-50
Gammans RE, Mayol RF, Labudde JA "Metabolism and disposition of buspirone." Am J Med 80 (1986): 41-51
"Product Information. Buspar (buspirone)." Bristol-Myers Squibb, Princeton, NJ.
Caccia S, Vigano GL, Mingardi G, et al "Clinical pharmacokinetics of oral buspirone in patients with impaired renal function." Clin Pharmacokinet 14 (1988): 171-7

Buspirone

Generic Name: buspirone

Brand Name: Buspar, Buspar Dividose, Vanspar, Buspirex, Bustab, LinBuspirone

Synonyms: BusPIRone

What is Buspirone?