Drug search by name

Abilify Discmelt and Liver disease

Result of checking the interaction of drug Abilify Discmelt and disease Liver disease for safety when used together.

Check result:

Abilify Discmelt <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Most neuroleptic agents are extensively metabolized by the liver. The plasma concentrations of these agents may be increased and the half-lives prolonged in patients with impaired hepatic function. Therapy with neuroleptic agents should be administered cautiously in patients with significant liver disease. Lower initial dosages and slower titration may be appropriate.

References:

Hobbs DC "Metabolism of thiothixene." J Pharm Sci 57 (1968): 105-11
"Product Information. Geodon (ziprasidone)." Pfizer US Pharmaceuticals, New York, NY.
Jann MW, Grimsley SR, Gray EC, Chang WH "Pharmacokinetics and pharmacodynamics of clozapine." Clin Pharmacokinet 24 (1993): 161-76
"Product Information. Moban (molindone)." Gate Pharmaceuticals, Sellersville, PA.
"Product Information. Clozaril (clozapine)." Novartis Pharmaceuticals, East Hanover, NJ.
Hobbs DC, Welch WM, Short MJ, Moody WA, Van der Velde CD "Pharmacokinetics of thiothixene in man." Clin Pharmacol Ther 16 (1974): 473-8
Heel RC, Brogden RN, Speight TM, Avery GS "Loxapine: a review of its pharmacological properties and therapeutic efficacy as an antipsychotic agent." Drugs 15 (1978): 198-217
"Product Information. Seroquel (quetiapine)." Zeneca Pharmaceuticals, Wilmington, DE.
"Product Information. Zyprexa (olanzapine)." Lilly, Eli and Company, Indianapolis, IN.
"Product Information. Navane (thiothixene)." Roerig Division, New York, NY.
"Product Information. Loxitane C Oral Concentrate (loxapine)" Watson Laboratories Inc, Corona, CA.