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Acthar Gel, H.P. and Scleroderma

Result of checking the interaction of drug Acthar Gel, H.P. and disease Scleroderma for safety when used together.

Check result:
Acthar Gel, H.P. <> Scleroderma
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of adrenocorticotropic agents is contraindicated in patients with scleroderma. Adrenocorticotropic agents may precipitate renal crisis with malignant hypertension in these patients, possibly via steroid-induced increases in renin substrate and angiotensin II levels and decreases in vasodilator prostaglandin production. Renal failure may ensue. If treatment is required for inflammatory myositis or pericarditis, glucocorticoids are preferable because of their more predictable pharmacologic effect. However, glucocorticoids should also be avoided in the long-term treatment of patients with scleroderma for similar reasons.

References:
  • "Product Information. Acthar (corticotropin)." Rhone-Poulenc Rorer, Collegeville, PA.
  • "Product Information. Acthrel (corticorelin)." Ferring Laboratories Inc, Tarrytown, NY.
  • "Product Information. Cortrosyn (cosyntropin)" Organon, West Orange, NJ.
Acthar Gel, H.P.

Generic Name: corticotropin

Brand Name: Acthar Gel, HP, Acthar, ACTH Gel, ACTH-80, ACTH-40 HP

Synonyms: H.P. Acthar Gel

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