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Bretylium Injection and Renal dysfunction

Result of checking the interaction of drug Bretylium Injection and disease Renal dysfunction for safety when used together.

Check result:

Bretylium Injection <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Bretylium is primarily eliminated by the kidney. Approximately 77% of bretylium is excreted in the urine unchanged. There are no known metabolites of bretylium. The serum concentration of bretylium is increased and the half-life prolonged in patients with renal impairment. Therapy with bretylium should be administered cautiously and the dosing interval increased in patients with compromised renal impairment. Clinical monitoring of cardiac function (ECG) and renal function is recommended. Bretylium is moderately removed during hemodialysis.

References:

Josselson J, Narang PK, Adir J, Yacobi A, Sadler JH "Bretylium kinetics in renal insufficiency." Clin Pharmacol Ther 33 (1983): 144-50
"Product Information. Bretylol (bretylium)." DuPont Pharmaceuticals, Wilmington, DE.
Adir J, Narang PK, Josselson J, Sadler JH "Pharmacokinetics of bretylium in renal insufficiency." N Engl J Med 300 (1979): 1390-1
Adir J, Narang PK, Josselson H, Sadler JH "Pharmacokinetics of bretylium in renal insufficiency." N Engl J Med 300 (1979): 1390-1
Adir J, Narang PK, Josselson J "Nomogram for bretylium dosing in renal impairment." Ther Drug Monit 7 (1985): 265-8

Bretylium Injection

Generic Name: bretylium

Brand Name:

Synonyms: Bretylium

What is Bretylium Injection?