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Acrivastine and pseudoephedrine and Renal dysfunction

Result of checking the interaction of drug Acrivastine and pseudoephedrine and disease Renal dysfunction for safety when used together.

Check result:

Acrivastine and pseudoephedrine <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Acrivastine is primarily eliminated by the kidney and may accumulate in patients with impaired renal function. Therapy with medications containing acrivastine should be administered cautiously in such patients. Due to the differential effects of renal failure on the serum half-life and clearance of acrivastine and pseudoephedrine, the use of products containing a fixed combination of these drugs is not recommended in the presence of renal impairment (CrCl <= 48 mL/min).

References:

"Product Information. Semprex-D (acrivastine-pseudoephedrine)." Endo Laboratories LLC, Chadds Ford, PA.
Cohen AF, Hamilton MJ, Liao SH, Findlay JW, Peck AW "Pharmacodynamic and pharmacokinetics of BW 825C: a new antihistamine." Eur J Clin Pharmacol 28 (1985): 197-204
Brater DC, Kaojarern S, Benet LZ, et al "Renal excretion of pseudoephedrine." Clin Pharmacol Ther 28 (1980): 690-4
Sica DA, Comstock TJ "Pseudoephedrine accumulation in renal failure." Am J Med Sci 298 (1989): 261-3

Acrivastine and pseudoephedrine

Generic Name: acrivastine / pseudoephedrine

Brand Name: Semprex-D

Synonyms: Acrivastine and Pseudoephedrine

What is Acrivastine and pseudoephedrine?