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Bisacodyl and polyethylene glycol (PEG) 3350 with electrolytes and GI irritation

Result of checking the interaction of drug Bisacodyl and polyethylene glycol (PEG) 3350 with electrolytes and disease GI irritation for safety when used together.

Check result:

Bisacodyl and polyethylene glycol (PEG) 3350 with electrolytes <> GI irritation

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of all solid oral formulations of potassium is contraindicated in patients with arrested or delayed gastrointestinal (GI) transit, whether due to structural, pathological, or pharmacological causes. Potassium is irritating to the GI mucosa and may cause ulcerative and/or stenotic lesions during prolonged physical contact. Based on spontaneous adverse reaction reports, the frequency of small bowel lesions associated with enteric-coated preparations of potassium chloride is 40 to 50 per 100,000 patient-years, while that for wax matrix controlled-release formulations is less than one per 100,000 patient years. Esophageal ulceration has also been reported following administration of controlled-release formulations of potassium chloride in cardiac patients with esophageal compression due to enlarged left atrium. Potassium supplementation should be administered as a liquid preparation or as an aqueous suspension in patients with esophageal obstruction and/or delayed gastrointestinal transit time.

Because of ulcerogenic effects, oral potassium should be administered cautiously in patients with peptic ulcers or other upper gastrointestinal diseases associated with inflammation, bleeding, or perforation. Patients should be advised not to crush, chew, or break potassium tablets or capsules, and to take them with meals and a full glass of water or other liquid. Potassium liquids should be diluted prior to consumption.

References:

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Bisacodyl and polyethylene glycol (PEG) 3350 with electrolytes

Generic Name: bisacodyl / polyethylene glycol 3350 / potassium chloride / sodium bicarbonate / sodium chloride

Brand Name: Half Lytely and Bisacodyl Lemon Lime, HalfLytely and Bisacodyl, HalfLytely and Bisacodyl with Flavor Packs, GaviLyte-H and Bisacodyl with Flavor Packs

Synonyms: Polyethylene Glycol-Electrolyte Solution and Bisacodyl

What is Bisacodyl and polyethylene glycol (PEG) 3350 with electrolytes?