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Betaxolol and Renal dysfunction

Result of checking the interaction of drug Betaxolol and disease Renal dysfunction for safety when used together.

Check result:

Betaxolol <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Betaxolol and its metabolites are eliminated by the kidney. Patients with renal impairment may be at greater risk for adverse effects from betaxolol due to decreased drug clearance. Therapy with betaxolol should be administered cautiously in patients with renal impairment. Dosage adjustments are recommended for patients with severe renal dysfunction (CrCl < 10 mL/min) or undergoing dialysis.

References:

"Product Information. Kerlone (betaxolol)." Searle, Skokie, IL.
Giudicelli JF, Chauvin M, Thuillez C, Richer C, Bianchetti G, Gomeni R, Morselli PL "Beta-adrenoceptor blocking effects and pharmacokinetics of betaxolol (SL 75212) in man." Br J Clin Pharmacol 10 (1980): 41-9
Beresford R, Heel RC "Betaxolol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension." Drugs 31 (1986): 6-28
Stagni G, Davis PJ, Ludden TM "Human pharmacokinetics of betaxolol enantiomers." J Pharm Sci 80 (1991): 321-4
Bianchetti G, Blatrix C, Gomeni R, Kilborn JR, Larribaud J, Lucker PW, Thebault JJ, Trocherie S, Morselli PL "Pharmacokinetics of the new beta-adrenoceptor blocking agent betaxolol (SL 75212) in man after repeated oral administration." Arzneimittelforschung 30 (1980): 1912-6
Bianchetti G, Thiercelin JF, Thenot JP "Pharmacokinetics of betaxolol in middle aged patients." Eur J Clin Pharmacol 31 (1986): 231-3

Betaxolol

Generic Name: betaxolol

Brand Name: Kerlone

Synonyms: Betaxolol (Systemic)

What is Betaxolol?