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Benemid and Uric acid nephrolithiasis

Result of checking the interaction of drug Benemid and disease Uric acid nephrolithiasis for safety when used together.

Check result:

Benemid <> Uric acid nephrolithiasis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of probenecid is not recommended in patients with a history of uric acid nephrolithiasis or a urinary urate excretion greater than 750 mg/24 hr. Probenecid may promote lithiasis by increasing uric acid concentration in the renal tubules. Adequate hydration is necessary during treatment. In general, a fluid intake sufficient to yield a daily urinary output of at least 2 liters is recommended. Maintenance of a slightly alkaline urine is also desirable.

References:

"Product Information. Benemid (probenecid)." Merck & Co, Inc, West Point, PA.
Gutman AB "Uricosuric drugs with special reference to probenecid and sulfinpyrazone." Adv Pharmacol 4 (1966): 91-142

Benemid

Generic Name: probenecid

Brand Name: Benemid

Synonyms: n.a.

What is Benemid?