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Abelcet and Renal dysfunction

Result of checking the interaction of drug Abelcet and disease Renal dysfunction for safety when used together.

Check result:

Abelcet <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Amphotericin B lipid complex is substantially less nephrotoxic than traditional amphotericin B but may still cause decreased renal function and abnormalities such as hypo- and hyperkalemia, hypomagnesemia, and renal tubular acidosis. Renal function should be monitored in all patients receiving therapy with amphotericin B lipid complex but particularly closely in patients with preexisting renal impairment. Serum creatinine, BUN, potassium and magnesium levels should be evaluated regularly, and dosing adjusted or discontinued if necessary. Hydration with normal saline may decrease the risk for nephrotoxicity. In addition, administration of alkali medication may help to prevent renal tubular acidosis.

References:

Gales MA, Gales BJ "Acute renal failure with amphotericin B in lipid emulsion." Ann Pharmacother 30 (1996): 1036
Block ER, Bennett JE, Livoti LG, Klein WJ, Roy R, Henderson L "Flucytosine and amphotericin B: hemodialysis effects on the plasma concentration and clearance." Ann Intern Med 80 (1974): 613-7
Sorkin P, Nagar H, Weinbroum A, Setton A, Israitel E, Scarlatt A, Silbiger A, Rudick V, Kluger Y, Halpern P "Administration of amphotericin b in lipid emulsion decreases nephrotoxicity: results of a prospective, randomized, controlled study in critically ill patients." Crit Care Med 24 (1996): 1311-5
"Product Information. Abelcet (amphotericin B)." Liposome Company Inc, The, Princeton, NJ.

Abelcet

Generic Name: amphotericin b lipid complex

Brand Name: Abelcet

Synonyms: n.a.

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