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Abelcet and Electrolyte disturbances

Result of checking the interaction of drug Abelcet and disease Electrolyte disturbances for safety when used together.

Check result:

Abelcet <> Electrolyte disturbances

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Amphotericin B lipid complex is substantially less nephrotoxic than traditional amphotericin B but may still cause hypo- and hyperkalemia, hypomagnesemia, and hypocalcemia secondary to renal impairment. Renal function and serum electrolytes should be monitored in all patients receiving therapy with amphotericin B lipid complex but particularly closely in patients with preexisting electrolyte abnormalities. Mineral and electrolyte supplementation may likely be required. Complications of electrolyte imbalances include muscle weakness, tetany, seizures and cardiac disturbances.

References:

Oravcova E, Mistrik M, Sakalova A, Drgona L, Kollar T, Helpianska L, Ilavska I, Sorkovska D, Spanik S, Kukuckova E, Krcmery V "Amphotericin b lipid complex to treat invasive fungal infections in cancer patients: report of efficacy and safety in 20 patients." Chemotherapy 41 (1995): 473-6
Kline S, Larsen TA, Fieber L, Fishbach R, Greenwood M, Harris R, Kline MW, Tennican PO, Janoff EN "Limited toxicity of prolonged therapy with high doses of amphotericin b lipid complex." Clin Infect Dis 21 (1995): 1154-8
"Product Information. Abelcet (amphotericin B)." Liposome Company Inc, The, Princeton, NJ.

Abelcet

Generic Name: amphotericin b lipid complex

Brand Name: Abelcet

Synonyms: n.a.

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