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Baycol and Renal dysfunction

Result of checking the interaction of drug Baycol and disease Renal dysfunction for safety when used together.

Check result:

Baycol <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Cerivastatin is partially eliminated by the kidney. Drug accumulation and prolonged half-life have been demonstrated in patients with moderate to severe renal impairment. Increased HMG-CoA reductase inhibitory activity may be associated with a greater risk of adverse effects, including hepatic and musculoskeletal toxicities. Therapy with cerivastatin should be administered cautiously in patients with renal impairment. The manufacturer recommends a reduced dosage in patients with CrCl <= 60 mL/min/1.73 m2.

References:

"Product Information. Baycol (cerivastatin)." Bayer, West Haven, CT.
Lennernas H, Fager G "Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences." Clin Pharmacokinet 32 (1997): 403-25
Mazzu A, Lettieri J, Kaiser L, Mullican W, Heller AH "Influence of age on the safety, tolerability, and pharmacokinetics of the novel HMG-CoA reductase inhibitor cerivastatin in healthy male volunteers." J Clin Pharmacol 38 (1998): 715-9

Baycol

Generic Name: cerivastatin

Brand Name: Baycol

Synonyms: n.a.

What is Baycol?