Drug search by name

Zyvox (Linezolid Suspension) and Renal dysfunction

Generic Name: linezolid
Dosage Forms: injection, tablets, oral suspension
Other Brand Names: Zyvox

Result of checking the interaction of drug Zyvox (Linezolid Suspension) and disease Renal dysfunction for safety when used together.

Check result:

Zyvox (Linezolid Suspension) <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Linezolid is primarily metabolized by the liver and subsequently eliminated by the kidney. The pharmacokinetics of the parent drug are not altered in patients with impaired renal function and, therefore, no dosage adjustments are necessary. However, accumulation of the two primary metabolites may occur in such patients, the amount of which increases with the degree of renal impairment. The clinical significance of metabolite accumulation has not been determined. Therapy with linezolid should be administered cautiously in patients with renal impairment and only if benefits outweigh the potential risks.

References: