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Zorvolex and Porphyria

Result of checking the interaction of drug Zorvolex and disease Porphyria for safety when used together.

Check result:
Zorvolex <> Porphyria
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

There has been an isolated report associating the use of diclofenac with precipitation of a porphyria attack. The proposed mechanism, demonstrated in rats, is through stimulation by diclofenac (and possibly other nonsteroidal anti-inflammatory agents) of the porphyrin precursor, delta-aminolevulinic acid. The manufacturer recommends avoiding diclofenac in patients with hepatic porphyria.

References:
  • "Product Information. Voltaren (diclofenac)." Novartis Pharmaceuticals, East Hanover, NJ.
Zorvolex

Generic Name: diclofenac

Brand Name: Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex, Voltaren, Dyloject, also Cambia

Synonyms: n.a.

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