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Baclofen Intrathecal and Psychoses

Result of checking the interaction of drug Baclofen Intrathecal and disease Psychoses for safety when used together.

Check result:
Baclofen Intrathecal <> Psychoses
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Baclofen may precipitate or exacerbate psychotic symptoms, both during therapy and following abrupt withdrawal of the drug. Therapy with baclofen should be administered cautiously in patients with a history of psychiatric disorders.

References:
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  • Lees AJ, Clarke CR, Harrison MJ "Hallucinations after sudden withdrawal of baclofen." Lancet 2 (1977): 44-5
  • Wolf ME, Almy G, Toll M, Mosnaim AD "Mania associated with the use of baclofen." Biol Psychiatry 17 (1982): 757-9
  • Siegfried RN, Jacobson L, Chabal C "Development of an acute withdrawal syndrome following the cessation of intrathecal baclofen in a patient with spasticity." Anesthesiology 77 (1992): 1048-50
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  • Garabedian-Ruffalo SM, Ruffalo RL "Adverse effects secondary to baclofen withdrawal." Drug Intell Clin Pharm 19 (1985): 304-6
  • Terrence CF, Fromm GH "Complications of baclofen withdrawal." Arch Neurol 38 (1981): 588-9
  • Jamous A, Kennedy P, Psychol C, Grey N "Psychological and emotional effects of the use of oral baclofen - a preliminary study." Paraplegia 32 (1994): 349-53
  • Yassa RY, Iskandar HL "Baclofen-induced psychosis: two cases and a review." J Clin Psychiatry 49 (1988): 318-20
  • Sommer BR, Petrides G "A case of baclofen-induced psychotic depression." J Clin Psychiatry 53 (1992): 211-2
  • Sandyk R, Gillman MA "Baclofen-induced memory impairment." Clin Neuropharmacol 8 (1985): 294-5
  • Rivas DA, Chancellor MB, Hill K, Freedman MK "Neurological manifestations of baclofen withdrawal." J Urol 150 (1993): 1903-5
  • Penn RD "Intrathecal baclofen for spasticity of spinal origin: seven years of experience." J Neurosurg 77 (1992): 236-40
  • Arnold ES, Rudd SM, Kirshner H "Manic psychosis following rapid withdrawal from baclofen." Am J Psychiatry 137 (1980): 1466-7
Baclofen Intrathecal

Generic Name: baclofen

Brand Name: Lioresal Intrathecal, Gablofen, FIRST Baclofen, Lioresal, Ozobax

Synonyms: Baclofen

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