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Zonegran and Oligohidrosis/hyperthermia

Result of checking the interaction of drug Zonegran and disease Oligohidrosis/hyperthermia for safety when used together.

Check result:

Zonegran <> Oligohidrosis/hyperthermia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Oligohidrosis (decreased sweating) and hyperthermia have been reported in association with the use of some carbonic anhydrase inhibitor anticonvulsants such as topiramate and zonisamide. Most of the reports have been in children. Caution and close monitoring of body temperature is advised when prescribing these drugs, especially in patients with a fever, in hot weather, or if combined with other drugs that predispose to heat related disorders. Zonisamide is not approved for use in pediatric patients in the U.S.

References:

"Product Information. Zonegran (zonisamide)" Elan Pharmaceuticals, S. San Francisco, CA.
Shimizu T, Yamashita Y, Satoi M, Togo A, Wada N, Matsuishi T, Ohnishi A, Kato H "Heat stroke-like episode in a child caused by zonisamide." Brain Dev 19 (1997): 366-8

Zonegran

Generic Name: zonisamide

Brand Name: Zonegran

Synonyms: n.a.

What is Zonegran?