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Zomig (Zolmitriptan Nasal Spray) and Renal dysfunction

Generic Name: zolmitriptan
Dosage Forms: tablet, tablet orally-disintegrating
Other Brand Names: Zomig , Zomig-ZMT

Result of checking the interaction of drug Zomig (Zolmitriptan Nasal Spray) and disease Renal dysfunction for safety when used together.

Check result:

Zomig (Zolmitriptan Nasal Spray) <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Zolmitriptan is excreted in the urine primarily as metabolites but also as unchanged drug. Following oral administration in patients with renal impairment, the clearance of zolmitriptan was not significantly altered in patients with moderate impairment (CrCl = 26 to 50 mL/min) but was reduced by 25% in patients with severe impairment (CrCl = 5 to 25 mL/min) compared to healthy controls. Therapy with rizatriptan should be administered cautiously in patients with significantly impaired renal function. A lower initial dosage may be appropriate.

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