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Zolpidem Sublingual Tablets (Intermezzo) and Drug dependence

Result of checking the interaction of drug Zolpidem Sublingual Tablets (Intermezzo) and disease Drug dependence for safety when used together.

Check result:

Zolpidem Sublingual Tablets (Intermezzo) <> Drug dependence

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Anxiolytic, sedative, and hypnotic agents have the potential to cause dependence and abuse. Tolerance as well as physical and psychological dependence can develop, particularly after prolonged use of excessive dosages, and abrupt cessation and/or a reduction in dosage may precipitate withdrawal symptoms. In patients who have developed tolerance, overdosage can still produce respiratory depression and death. Therapy with anxiolytic, sedative, and hypnotic agents should be administered cautiously and for as brief a period as possible. Addiction-prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance or medical supervision when treated with these agents. In addition, it may be prudent to refrain from dispensing large quantities of medication to such patients. After prolonged use or if dependency is suspected, withdrawal of medication should be undertaken gradually using a dosage-tapering schedule.

References:

Gericke CA, Ludolph AC "Chronic abuse of zolpidem." JAMA 272 (1994): 1721-2
Cavallaro R, Regazzetti MG, Covelli G, Smeraldi E "Tolerance and withdrawal with zolpidem." Lancet 342 (1993): 374-5
"Product Information. Placidyl (ethchlorvynol)." Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Ambien (zolpidem)." sanofi-aventis, Bridgewater, NJ.
"Product Information. Sonata (zaleplon)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Aquachloral Supprettes (chloral hydrate)." Medisca, Plattsburg, NY.
"Product Information. Equanil (meprobamate)." Wallace Laboratories, Cranbury, NJ.

Zolpidem Sublingual Tablets (Intermezzo)

Generic Name: zolpidem

Brand Name: Ambien, Ambien CR, Edluar, Intermezzo, ZolpiMist

Synonyms: Zolpidem

What is Zolpidem Sublingual Tablets (Intermezzo)?