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Zoloft and Renal dysfunction
Result of checking the interaction of drug Zoloft and disease Renal dysfunction for safety when used together.
Check result:
Zoloft <> Renal dysfunction
Relevance: 23.07.2019
Reviewer: Shkutko P.M., M.D., in
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Sertraline is primarily metabolized by the liver. Although renal excretion of unchanged drug appears to be a minor route of elimination, some metabolites are excreted in the urine to some extent. The clinical significance of possible metabolite accumulation is unknown. Caution may be warranted when sertraline therapy is administered in patients with severe renal dysfunction.
References:
- "Product Information. Zoloft (sertraline)." Roerig Division, New York, NY.
- Guthrie SK "Sertraline: a new specific serotonin reuptake blocker." DICP 25 (1991): 952-61
- Murdoch D, McTavish D "Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive- compulsive disorder." Drugs 44 (1992): 604-24
- Doogan DP, Caillard V "Sertraline: a new antidepressant." J Clin Psychiatry 49 (1988): 46-51
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