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Zolgensma and Liver dysfunction

Result of checking the interaction of drug Zolgensma and disease Liver dysfunction for safety when used together.

Check result:

Zolgensma <> Liver dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of onasemnogene abeparvovec-xioi can increase liver enzyme levels and cause acute serious liver injury. Close monitoring is recommended in patients with pre-existing liver impairment as they may be at higher risk. It is recommended to assess liver function of all patients by clinical examination and laboratory testing (e.g., hepatic aminotransferases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)], total bilirubin, and prothrombin time) prior to infusion. Continue to monitor liver function for at least 3 months after infusion; weekly for the first month, and then every other week for the second and third months, until results are unremarkable. Administer systemic corticosteroid to all patients before and after onasemnogene abeparvovec-xioi infusion.

Zolgensma

Generic Name: onasemnogene abeparvovec

Brand Name: Zolgensma, Zolgensma

Synonyms: n.a.

What is Zolgensma?