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Zofran (Ondansetron Oral Solution) and Liver disease

Result of checking the interaction of drug Zofran (Ondansetron Oral Solution) and disease Liver disease for safety when used together.

Check result:

Zofran (Ondansetron Oral Solution) <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Ondansetron is extensively metabolized by the liver. The plasma clearance of ondansetron may be substantially decreased and the half-life prolonged in patients with impaired hepatic function. During clinical trials in patients receiving concomitant chemotherapy, transient elevations of serum transaminases and isolated cases of jaundice have been reported. Therapy with ondansetron should be administered cautiously at reduced dosages in patients with liver disease. The manufacturer recommends a maximum daily dosage of 8 mg in severe hepatic impairment.

References:

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Blake JC, Palmer JL, Minton NA, Burroughs AK "The pharmacokinetics of intravenous ondansetron in patients with hepatic impairment." Br J Clin Pharmacol 35 (1993): 441-3
Figg WE, Dukes GE, Pritchard JF, et al. "Ondansetron (OND) pharmacokinetics in chronic liver disease (LD)." Clin Pharmacol Ther 51 (1992): 171
Roila F, Delfavero A "Ondansetron clinical pharmacokinetics." Clin Pharmacokinet 29 (1995): 95-109
Bryson JC "Clinical safety of ondansetron." Semin Oncol 19 (1992): 26-32
Finn AL "Toxicity and side effects of ondansetron." Semin Oncol 19 (1992): 53-60
"Product Information. Zofran (ondansetron)." Cerenex Pharmaceuticals, Research Triangle Pk, NC.
Verrill M, Judson I "Jaundice with ondansetron." Lancet 344 (1994): 190-1
Figg WD, Dukes GE, Pritchard JF, Hermann DJ, Lesesne HR, Carson SW, Songer SS, Powell R, Hak LJ "Pharmacokinetics of ondansetron in patients with hepatic insufficiency." J Clin Pharmacol 36 (1996): 206-15

Zofran (Ondansetron Oral Solution)

Generic Name: ondansetron

Brand Name: Zofran, Zofran ODT, Zuplenz

Synonyms: Zofran

What is Zofran (Ondansetron Oral Solution)?