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Zithromax Injection and Liver disease

Result of checking the interaction of drug Zithromax Injection and disease Liver disease for safety when used together.

Check result:

Zithromax Injection <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Azithromycin is primarily excreted by the hepatobiliary system. Although the drug is generally well-tolerated and associated with few adverse effects, therapy with azithromycin should be administered cautiously in patients with liver and/or biliary disease. Hepatotoxicity (abnormal liver function, hepatitis, cholestatic jaundice, necrosis and hepatic failure) has been reported. Treatment should be discontinued immediately if signs and symptoms of hepatitis occur. Azithromycin is contraindicated in patients with a history of cholestatic jaundice or hepatic dysfunction associated with the prior use of azithromycin.

References:

"Product Information. Azithromycin Product Information (azithromycin)." Pfizer US Pharmaceuticals, New York, NY.
Zuckerman JM, Kaye KM "The newer macrolides: azithromycin and clarithromycin." Infect Dis Clin North Am 9 (1995): 731-45
Hopkins S "Clinical toleration and safety of azithromycin." Am J Med 91 (1991): s41-5
Chave J, Munafo A, Chatton JY, Dayer P, Glauser MP, Biollaz J "Once-a-week azithromycin in AIDS patients: tolerability, kinetics, and effects on zidovudine disposition." Antimicrob Agents Chemother 36 (1992): 1013-18

Zithromax Injection

Generic Name: azithromycin

Brand Name: AzaSite, Azithromycin 3 Day Dose Pack, Azithromycin 5 Day Dose Pack, Zithromax, Zithromax Tri-Pak, Zithromax Z-Pak, Zmax, Zithromax IV

Synonyms: Azithromycin, Azithromycin (Systemic)

What is Zithromax Injection?