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Zilretta and PUD

Result of checking the interaction of drug Zilretta and disease PUD for safety when used together.

Check result:

Zilretta <> PUD

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Corticosteroids may cause peptic ulcer disease and gastrointestinal (GI) hemorrhage, usually when given in high dosages or for prolonged periods. However, even conventional dosages may aggravate symptoms in patients with a history of peptic ulcers. Delayed healing of ulcers has also been reported. Therapy with corticosteroids should be avoided or administered cautiously in patients with active or latent peptic ulcers or other risk factors for GI bleeding. Some clinicians recommend the use of prophylactic antacids or H2-antagonists between meals when large doses of corticosteroids are necessary.

References:

Heimdal K, Hirschberg H, Slettebo H, Watne K, Nome O, Sletteb H "High incidence of serious side effects of high-dose dexamethasone treatment in patients with epidural spinal cord compression." J Neurooncol 12 (1992): 141-4
Thomas TP "The complications of systemic corticosteroid therapy in the elderly." Gerontology 30 (1984): 60-5
"Product Information. Kenalog (triamcinolone)." Bristol-Myers Squibb, Princeton, NJ.
Weissman DE, Dufer D, Vogel V, Abeloff MD "Corticosteroid toxicity in neuro-oncology patients." J Neurooncol 5 (1987): 125-8
"Product Information. Florinef Acetate (fludrocortisone)." Bristol-Myers Squibb, Princeton, NJ.
Lieberman P, Patterson R, Kunske R "Complications of long-term steroid therapy for asthma." J Allergy Clin Immunol 49 (1972): 329-36
"Product Information. Decadron (dexamethasone)." Merck & Co, Inc, West Point, PA.
Allan SG, Leonard RC "Dexamethasone antiemesis and side-effects." Lancet 1 (1986): 1035
"Product Information. Deltasone (prednisone)." Pharmacia and Upjohn, Kalamazoo, MI.
Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42
Baethge BA, Lidsky MD, Goldberg JW "A study of adverse effects of high-dose intravenous (pulse) methylprednisolone therapy in patients with rheumatic disease." Ann Pharmacother 26 (1992): 316-20
Messer J, Reitman D, Sacks HS, et al "Association of adrenocorticosteroid therapy and peptic-ulcer disease." N Engl J Med 309 (1983): 21-4
Pang S, Clark AT, Freeman LC, Dolan LM, Immken L, Mueller OT, Stiff D, Shulman DI "Maternal side effects of prenatal dexamethasone therapy for fetal congenital adrenal hyperplasia." J Clin Endocrinol Metab 75 (1992): 249-53
"Product Information. Hydrocortone (hydrocortisone)." Merck & Co, Inc, West Point, PA.
"Product Information. Hydeltrasol (prednisolone)." Merck & Co, Inc, West Point, PA.
"Product Information. Cortone Acetate (cortisone)." Merck & Co, Inc, West Point, PA.
"Product Information. Celestone (betamethasone)." Schering Corporation, Kenilworth, NJ.
Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998):
"Product Information. Medrol (methylprednisolone)." Pharmacia and Upjohn, Kalamazoo, MI.
Swartz SL, Dluhy RG "Corticosteroids: clinical pharmacology and therapeutic use." Drugs 16 (1978): 238-55
Chrousos GA, Kattah JC, Beck RW, Cleary PA "Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial." JAMA 269 (1993): 2110-2