Drug search by name

Zilretta and GI perforation

Result of checking the interaction of drug Zilretta and disease GI perforation for safety when used together.

Check result:

Zilretta <> GI perforation

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Corticosteroids may cause gastrointestinal perforation and hemorrhage, usually when given in high dosages or for prolonged periods. They may also mask symptoms of complications such as peritonitis or intraabdominal sepsis. Therapy with corticosteroids should be avoided or administered cautiously in patients with diverticulitis, nonspecific ulcerative colitis (if there is a probability of impending perforation, abscess, or other pyogenic infection), or recent intestinal anastomoses.

References:

Fadul CE, Lemann W, Thaler HT, Posner JB "Perforation of the gastrointestinal tract in patients receiving steroids for neurologic disease." Neurology 38 (1988): 348-52
"Product Information. Celestone (betamethasone)." Schering Corporation, Kenilworth, NJ.
"Product Information. Medrol (methylprednisolone)." Pharmacia and Upjohn, Kalamazoo, MI.
Chrousos GA, Kattah JC, Beck RW, Cleary PA "Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial." JAMA 269 (1993): 2110-2
"Product Information. Cortone Acetate (cortisone)." Merck & Co, Inc, West Point, PA.
Swartz SL, Dluhy RG "Corticosteroids: clinical pharmacology and therapeutic use." Drugs 16 (1978): 238-55
"Product Information. Hydrocortone (hydrocortisone)." Merck & Co, Inc, West Point, PA.
Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42
"Product Information. Decadron (dexamethasone)." Merck & Co, Inc, West Point, PA.
Thomas TP "The complications of systemic corticosteroid therapy in the elderly." Gerontology 30 (1984): 60-5
"Product Information. Hydeltrasol (prednisolone)." Merck & Co, Inc, West Point, PA.
ReMine SG, McIlrath DC "Bowel perforation in steroid-treated patients." Ann Surg 192 (1980): 581-6
Bohrer H, Schmidt H, Bach A, Bottiger BW, Motsch J "Masking of the symptoms of esophageal and bowel perforation by combination treatment of sepsis with polyvalent immunoglobulins and low-dose hydrocortisone." Hepatogastroenterology 43 (1996): 515-8
Heimdal K, Hirschberg H, Slettebo H, Watne K, Nome O, Sletteb H "High incidence of serious side effects of high-dose dexamethasone treatment in patients with epidural spinal cord compression." J Neurooncol 12 (1992): 141-4
"Product Information. Deltasone (prednisone)." Pharmacia and Upjohn, Kalamazoo, MI.
Baethge BA, Lidsky MD, Goldberg JW "A study of adverse effects of high-dose intravenous (pulse) methylprednisolone therapy in patients with rheumatic disease." Ann Pharmacother 26 (1992): 316-20
"Product Information. Kenalog (triamcinolone)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Florinef Acetate (fludrocortisone)." Bristol-Myers Squibb, Princeton, NJ.