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Zidovudine Oral Solution and Bone marrow suppression

Result of checking the interaction of drug Zidovudine Oral Solution and disease Bone marrow suppression for safety when used together.

Check result:

Zidovudine Oral Solution <> Bone marrow suppression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Zidovudine (AZT) may cause bone marrow toxicity, most commonly manifested as granulocytopenia and anemia, particularly in patients with advanced, symptomatic HIV disease. Thrombocytopenia not related to HIV may also occasionally occur. Zidovudine should be given with extreme caution to patients with preexisting bone marrow depression (indicated by a granulocyte count below 1000 cells/mm3 or hemoglobin less than 9.5 g/dL) or blood dyscrasias. Routine blood counts are recommended, and generally should occur more frequently in patients with advanced HIV disease. Dosage reductions may be necessary.

References:

Moore RD, Fortgang I, Keruly J, Chaisson RE "Adverse events from drug therapy for human immunodeficiency virus disease." Am J Med 101 (1996): 34-40
Goldsmith JC, Irvine W "Reversible agranulocytosis related to azidothymidine therapy." Am J Hematol 30 (1989): 263-4
Baum MK, Javier JJ, Mantero-Atienza E, et al "Zidovudine-associated adverse reactions in a longitudinal study of asymptomatic HIV-1-infected homosexual males." J Acquir Immune Defic Syndr 4 (1991): 1218-26
"Product Information. Retrovir (zidovudine)." Glaxo Wellcome, Research Triangle Park, NC.

Zidovudine Oral Solution

Generic Name: zidovudine

Brand Name: Retrovir

Synonyms: Zidovudine (oral/injection), Zidovudine

What is Zidovudine Oral Solution?