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Zanaflex and Hypotension

Result of checking the interaction of drug Zanaflex and disease Hypotension for safety when used together.

Check result:

Zanaflex <> Hypotension

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tizanidine is a centrally-acting alpha-2 adrenergic agonist with 1/10 to 1/50 the potency of clonidine in lowering blood pressure. According to the manufacturer, two-thirds of patients in a study given single 8 mg doses of tizanidine had a 20% reduction in either the diastolic or systolic blood pressure. The effect was seen one hour after dosing and peaked at 2 to 3 hours post-dose. Bradycardia, orthostatic hypotension, lightheadedness, dizziness and, rarely, syncope have occurred. Therapy with tizanidine should be administered cautiously in patients with or predisposed to hypotension. The risk of significant hypotension may be minimized by gradual dosage titration. Patients should be advised not to rise abruptly from a supine position.

References:

Wallace JD "Summary of combined clinical analysis of controlled clinical trials with tizanidine." Neurology 44 (11 sup (1994): s60-8;dic. 68-9
"Product Information. Zanaflex (tizanidine)." Acorda Therapeutics, Hawthorne, NY.

Zanaflex

Generic Name: tizanidine

Brand Name: Zanaflex

Synonyms: n.a.

What is Zanaflex?