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Vfend I.V. and Renal dysfunction

Generic Name: voriconazole
Dosage Forms: n.a.
Other Brand Names: Vfend , Vfend

Result of checking the interaction of drug Vfend I.V. and disease Renal dysfunction for safety when used together.

Check result:

Vfend I.V. <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The pharmacokinetics of voriconazole are not significantly altered in patients with impaired renal function. However, accumulation of the intravenous vehicle, sulfobutyl ether beta-cyclodextrin sodium (SBECD), has been demonstrated in patients with moderate renal dysfunction. The mean systemic exposure (AUC) and peak plasma concentrations (Cmax) of SBECD were increased by 4-fold and almost 50%, respectively, compared to controls with normal renal function. The manufacturer recommends that the intravenous formulation of voriconazole not be used in patients with moderate to severe renal impairment (CrCl < 50 mL/min), unless benefit outweighs the potential risk. No dosage adjustment is necessary when using the oral formulation of voriconazole. However, continued monitoring of renal function for further deterioration is recommended.

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