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Verapamil Hydrochloride PM and Aortic stenosis

Result of checking the interaction of drug Verapamil Hydrochloride PM and disease Aortic stenosis for safety when used together.

Check result:

Verapamil Hydrochloride PM <> Aortic stenosis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of some calcium channel blockers (CCBs) is contraindicated in patients with advanced aortic stenosis. CCBs whose pharmacologic effect is partially dependent on their ability to reduce afterload (e.g., diltiazem, nicardipine, nifedipine, verapamil) may be of less benefit in these patients due to a fixed impedance to flow across the aortic valve and may, in fact, worsen rather than improve myocardial oxygen balance. Rarely, heart failure has developed following the initiation of these CCBs, particularly in patients receiving concomitant beta-blocker therapy.

References:

"Product Information. Adalat (nifedipine)." Bayer, West Haven, CT.
"Product Information. Procardia (nifedipine)." Pfizer US Pharmaceuticals, New York, NY.
"Product Information. Cardene (nicardipine)." Syntex Laboratories Inc, Palo Alto, CA.

Verapamil Hydrochloride PM

Generic Name: verapamil

Brand Name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM

Synonyms: Verapamil

What is Verapamil Hydrochloride PM?