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Venlafaxine ER and Renal/liver disease

Result of checking the interaction of drug Venlafaxine ER and disease Renal/liver disease for safety when used together.

Check result:

Venlafaxine ER <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Venlafaxine is metabolized by the liver, and both the parent drug and metabolites are excreted by the kidney. Patients with renal and/or liver disease may be at greater risk for adverse effects from venlafaxine due to decreased drug clearance. Therapy with venlafaxine should be administered cautiously in patients with impaired renal and/or hepatic function. A reduction in the total daily dosage is recommended. The manufacturer suggests a 50% reduction in patients with moderate hepatic impairment (possibly more in patients with cirrhosis), a 25% reduction in patients with mild to moderate renal impairment, and a 50% reduction in patients undergoing hemodialysis (to be administered after dialysis treatment).

References:

"Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Klamerus KJ, Maloney K, Rudolph RL, Sisenwine SF, Jusko WJ, Chiang ST "Introduction of a composite parameter to the pharmacokinetics of venlafaxine and its active O-desmethyl metabolite." J Clin Pharmacol 32 (1992): 716-24

Venlafaxine ER

Generic Name: venlafaxine

Brand Name: Effexor XR, Effexor

Synonyms: Venlafaxine

What is Venlafaxine ER?