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Valsartan and Hydrochlorothiazide and Renal/liver disease

Generic Name: hydrochlorothiazide / valsartan
Dosage Forms: n.a.
Other Brand Names: Diovan HCT

Result of checking the interaction of drug Valsartan and Hydrochlorothiazide and disease Renal/liver disease for safety when used together.

Check result:

Valsartan and Hydrochlorothiazide <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Valsartan is primarily eliminated by biliary excretion, and a minority is excreted in the urine. Dosage adjustments are not necessary in patients with renal impairment unless they are also volume-depleted, in which case therapy should be initiated under medical supervision. Likewise, patients with mild to moderate hepatic impairment or biliary obstruction generally do not require a dosage adjustment. The manufacturer recommends administering valsartan therapy with caution in patients with impaired renal and/or liver function, particularly if these conditions are severe.

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