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Axert and Renal dysfunction

Generic Name: almotriptan
Dosage Forms: tablet, coated
Other Brand Names: Axert

Result of checking the interaction of drug Axert and disease Renal dysfunction for safety when used together.

Check result:

Axert <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Approximately 40% of an administered dose of almotriptan is excreted unchanged in the urine. Following oral administration in patients with renal impairment, the clearance of almotriptan was approximately 65% lower in patients with severe impairment (CrCl = 10 to 30 mL/min) and 40% lower in patients with moderate impairment (CrCl = 31 to 71 mL/min) compared to healthy controls. Peak plasma concentrations of almotriptan increased by approximately 80% in these patients. The manufacturer recommends that a starting dose of 6.25 mg be used in patients with significantly impaired renal function, and that the maximum dosage not exceed 12.5 mg per 24-hour period.

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