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Trinipatch 0.2 and Hypotension

Result of checking the interaction of drug Trinipatch 0.2 and disease Hypotension for safety when used together.

Check result:

Trinipatch 0.2 <> Hypotension

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Organic nitrates and nitrites may cause severe hypotension, syncope and shock, even with small doses. Hypotension induced by these agents may be accompanied by paradoxical bradycardia and increased angina pectoris. Therapy with nitrates and nitrites should be administered cautiously in patients who are volume-depleted or hypotensive (e.g., systolic blood pressure <90 mm Hg) or who, because of inadequate circulation to the brain or to other vital organs, would be unusually compromised by undue hypotension. Patients should be in a sitting or recumbent position during and immediately after drug administration, and monitored for symptoms of severe hypotension such as nausea, vomiting, weakness, pallor, perspiration, and syncope. Nitrate or nitrite therapy is considered contraindicated in patients with acute circulatory failure or shock.

References:

"Product Information. ISMO (isosorbide mononitrate)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Tridil (nitroglycerin)." DuPont Pharmaceuticals, Wilmington, DE.
Ong EA, Bass S "Nitroglycerin-induced bradycardia and hypotension in acute myocardial infarction." Chest 77 (1980): 244
Purvin VA, Dunn DW "Nitrate-induced transient ischemic attacks." South Med J 74 (1981): 1130-1
Brandes W, Santiago T, Limacher M "Nitroglycerin-induced hypotension, bradycardia, and asystole: report of a case and review of the literature." Clin Cardiol 13 (1990): 741-4
von Arnim T, Autenrieth G, Bolte HD "Acute myocardial infarction during continuous electrocardiographic ST segment recording. Possible role of bradycardia and hypotension induced by glyceryl trinitrate." Br Heart J 51 (1984): 575-7
Nemerovski M, Shah PK "Syndrome of severe bradycardia and hypotension following sublingual nitroglycerin administration." Cardiology 67 (1981): 180-9
"Product Information. Nitrostat (nitroglycerin)." Parke-Davis, Morris Plains, NJ.
Lancaster L, Fenster PE "Complete heart block after sublingual nitroglycerin." Chest 84 (1983): 111-2
Buckley R, Roberts R "Symptomatic bradycardia following the administration of sublingual nitroglycerin." Am J Emerg Med 11 (1993): 253-5
"Product Information. Isordil (isosorbide dinitrate)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Cunningham J "Hypotension following administration of sublingual nitroglycerin ." Heart Lung 8 (1979): 364

Trinipatch 0.2

Generic Name: nitroglycerin

Brand Name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: Nitroglycerin (oral/sublingual), Nitroglycerin

What is Trinipatch 0.2?