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Trinipatch 0.2 and Anemia

Result of checking the interaction of drug Trinipatch 0.2 and disease Anemia for safety when used together.

Check result:

Trinipatch 0.2 <> Anemia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Some manufacturers and medical references consider the use of nitrates and nitrites to be contraindicated in patients with severe anemia. Nitrates and nitrites can cause methemoglobinemia, primarily in high-dose intravenous therapy or acute poisoning and in patients with NADH reductase deficiency. However, elevations of methemoglobin may also occur with commonly used dosages. While probably not of routine clinical significance, the increases may be important in certain patient populations such as those with coronary insufficiency or anemia.

References:

Saxon SA, Silverman ME "Effects of continuous infusion of intravenous nitroglycerin on methemoglobin levels." Am J Cardiol 56 (1985): 461-4
Arsura E, Lichstein E, Guadagnino V, Nicchi V, Sanders M, Hollander G, Greengart A "Methemoglobin levels produced by organic nitrates in patients with coronary artery disease." J Clin Pharmacol 24 (1984): 160-4
Pierce JM, Nielsen MS "Acute acquired methaemoglobinaemia after amyl nitrite poisoning." BMJ 298 (1989): 1566
Edwards RJ, Ujma J "Extreme methaemoglobinaemia secondary to recreational use of amyl nitrite." J Accid Emerg Med 12 (1995): 138-42
Kaplan K, Davison R "Nitroglycerin and methemoglobinemia." Am J Cardiol 57 (1986): 1004
Sobey RJ, Campbell CM "A 37-year-old with amyl nitrite-induced methemoglobinemia." J Emerg Nurs 18 (1992): 11-3
"Product Information. Nitrostat (nitroglycerin)." Parke-Davis, Morris Plains, NJ.
Forsyth RJ, Moulden A "Methaemoglobinaemia after ingestion of amyl nitrite." Arch Dis Child 66 (1991): 152
Machabert R, Testud F, Descotes J "Methaemoglobinaemia due to amyl nitrite inhalation: a case report." Hum Exp Toxicol 13 (1994): 313-4
Sutton M, Jeffrey B "Acquired methemoglobinemia from amyl nitrate inhalation." J Emerg Nurs 18 (1992): 8-9
Gibson GR, Hunter JB, Raabe DS, Jr Manjoney DL, Ittleman FP "Methemoglobinemia produced by high-dose intravenous nitroglycerin." Ann Intern Med 96 (1982): 615-6
Curry SC, Arnold-Capell P "Toxic effects of drugs used in the ICU. Nitroprusside, nitroglycerin, and angiotensin-converting enzyme inhibitors." Crit Care Clin 7 (1991): 555-81
Fibuch EE, Cecil WT, Reed WA "Methemoglobinemia associated with organic nitrate therapy." Anesth Analg 58 (1979): 521-3
Robicsek F "Acute methemoglobinemia during cardiopulmonary bypass caused by intravenous nitroglycerin infusion." J Thorac Cardiovasc Surg 90 (1985): 931-4

Trinipatch 0.2

Generic Name: nitroglycerin

Brand Name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: Nitroglycerin (oral/sublingual), Nitroglycerin

What is Trinipatch 0.2?