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Trazodone Hydrochloride and Renal/liver disease

Result of checking the interaction of drug Trazodone Hydrochloride and disease Renal/liver disease for safety when used together.

Check result:

Trazodone Hydrochloride <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Trazodone undergoes metabolism in the liver. The metabolites, at least one of which is pharmacologically active, are excreted by the kidney. There are no data available concerning the pharmacokinetic disposition of trazodone or its metabolites in patients with renal and/or liver disease. Therapy with trazodone should be administered cautiously in patients with significantly impaired renal or hepatic function. Dosage adjustments may be necessary.

References:

Greenblatt DJ, Friedman H, Burstein ES, et al. "Trazadone kinetics: effect of age, gender, and obesity." Clin Pharmacol Ther 42 (1987): 193-200
Nilsen OG, Dale O "Single dose pharmacokinetics of trazodone in healthy subjects." Pharmacol Toxicol 71 (1992): 150-3
"Product Information. Desyrel (trazodone)." Bristol-Myers Squibb, Princeton, NJ.

Trazodone Hydrochloride

Generic Name: trazodone

Brand Name: Desyrel, Desyrel Dividose, Oleptro

Synonyms: Trazodone, TraZODone

What is Trazodone Hydrochloride?