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Trazodone Hydrochloride and Hypotension

Result of checking the interaction of drug Trazodone Hydrochloride and disease Hypotension for safety when used together.

Check result:

Trazodone Hydrochloride <> Hypotension

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Trazodone has alpha-1 adrenergic blocking activity and may cause hypotension (including orthostatic hypotension) in approximately 5% of patients. Therapy with trazodone should be administered cautiously in patients with hypotension or conditions that could be exacerbated by hypotension, such as a history of myocardial infarction, angina, or ischemic stroke. Patients with dehydration (e.g., due to severe diarrhea or vomiting) may be predisposed to hypotension and should also be managed carefully during therapy with trazodone. Blood pressure should be monitored at regular intervals, particularly during dosage escalation or whenever dosage has been altered, and patients should be advised not to rise abruptly from a sitting or recumbent position.

References:

Spivak B, Radvan M, Shine M "Postural hypotension with syncope possibly precipitated by trazodone." Am J Psychiatry 144 (1987): 1512-3
"Product Information. Desyrel (trazodone)." Bristol-Myers Squibb, Princeton, NJ.

Trazodone Hydrochloride

Generic Name: trazodone

Brand Name: Desyrel, Desyrel Dividose, Oleptro

Synonyms: Trazodone, TraZODone

What is Trazodone Hydrochloride?