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Tranylcypromine and Seizures

Result of checking the interaction of drug Tranylcypromine and disease Seizures for safety when used together.

Check result:

Tranylcypromine <> Seizures

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Monoamine oxidase inhibitor (MAOI) antidepressants may have variable effects on seizure threshold. Decreased seizure frequency as well as increased frequency have been reported. Therapy with MAOI antidepressants should be administered cautiously in patients with a history of seizures.

References:

"Product Information. Marplan (isocarboxazid)" Roche Laboratories, Nutley, NJ.
"Product Information. Nardil (phenelzine)." Parke-Dvis, Morris Plains, NJ.
"Product Information. Parnate (tranylcypromine)." SmithKline Beecham, Philadelphia, PA.
Waghray SN, Francis K "Epilepsy as an adverse reaction to combined therapy of MAOIs and tricyclics." J R Soc Med 77 (1984): 346
Pascual J, Combarros O, Berciano J "Partial status epilepticus following single low dose of chlorimipramine in a patient on MAO-inhibitor treatment." Clin Neuropharmacol 10 (1987): 565-7

Tranylcypromine

Generic Name: tranylcypromine

Brand Name: Parnate

Synonyms: n.a.

What is Tranylcypromine?