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Tranylcypromine and Pheochromocytoma

Result of checking the interaction of drug Tranylcypromine and disease Pheochromocytoma for safety when used together.

Check result:

Tranylcypromine <> Pheochromocytoma

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of nonspecific monoamine oxidase inhibitors (MAOIs) is contraindicated in patients with pheochromocytoma or other tumors of the adrenal medulla, such as some neuroblastomas, that secrete pressor substances. Nonspecific MAOIs inhibit the breakdown of pressor amines, the accumulation of which can precipitate hypertensive crises. Intracranial hemorrhage and death have resulted in some cases.

References:

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Rabkin J, Quitkin F, Harrison W, Tricamo E, McGrath P "Adverse reactions to monoamine oxidase inhibitors. Part I. A comparative study." J Clin Psychopharmacol 4 (1984): 270-8
"Product Information. Parnate (tranylcypromine)." SmithKline Beecham, Philadelphia, PA.
Fallon B, Foote B, Walsh BT, Roose SP "'Spontaneous' hypertensive episodes with monoamine oxidase inhibitors." J Clin Psychiatry 49 (1988): 163-5
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Robinson DS, Nies A, Corcella J, Cooper TB, Spencer C, Keefover R "Cardiovascular effects of phenelzine and amitriptyline in depressed outpatients." J Clin Psychiatry 43 (1982): 8-15
"Product Information. Nardil (phenelzine)." Parke-Dvis, Morris Plains, NJ.
Linet LS "Mysterious MAOI hypertensive episodes." J Clin Psychiatry 47 (1986): 563-5
Rabkin JG, Quitkin FM, McGrath P, Harrison W, Tricamo E "Adverse reactions to monoamine oxidase inhibitors. Part II. Treatment correlates and clinical management." J Clin Psychopharmacol 5 (1985): 2-9
"Product Information. Marplan (isocarboxazid)" Roche Laboratories, Nutley, NJ.

Tranylcypromine

Generic Name: tranylcypromine

Brand Name: Parnate

Synonyms: n.a.

What is Tranylcypromine?

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