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Tranylcypromine and Liver disease

Result of checking the interaction of drug Tranylcypromine and disease Liver disease for safety when used together.

Check result:

Tranylcypromine <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of monoamine oxidase inhibitor (MAOI) antidepressants is contraindicated in patients with abnormal liver function tests or a history of liver disease. A low incidence of altered liver function or hepatocellular jaundice has been reported in association with the use of MAOI antidepressants. Periodic monitoring of liver function tests is recommended during prolonged and/or high-dose therapy.

References:

Gomezgil E, Salmeron JM, Mas A "Phenelzine-induced fulminant hepatic failure." Ann Intern Med 124 (1996): 692-3
"Product Information. Nardil (phenelzine)." Parke-Dvis, Morris Plains, NJ.
Bonkovsky HL, Blanchette PL, Schned AR "Severe liver injury due to phenelzine with unique hepatic deposition of extracellular material." Am J Med 80 (1986): 689-92
"Product Information. Marplan (isocarboxazid)" Roche Laboratories, Nutley, NJ.
Robinson DS, Kurtz NM "What is the degree of risk of hepatotoxicity for depressed patients receiving phenelzine therapy? Is the risk sufficient to require that we modify the written advice (as to diet and risks) that we regularly give our patients before we institute this..." J Clin Psychopharmacol 7 (1987): 61-2
Zimmerman HJ, Ishak KG "The hepatic injury of monoamine oxidase inhibitors." J Clin Psychopharmacol 7 (1987): 211-3
"Product Information. Parnate (tranylcypromine)." SmithKline Beecham, Philadelphia, PA.

Tranylcypromine

Generic Name: tranylcypromine

Brand Name: Parnate

Synonyms: n.a.

What is Tranylcypromine?

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