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Topamax (Topiramate Sprinkle Capsules) and Hemodialysis

Generic Name: topiramate
Dosage Forms: tablet, coated; capsule, coated pellets
Other Brand Names: Qudexy XR , Topamax , Topamax Sprinkle , Topiragen , Trokendi XR , Qudexy XR Sprinkle

Result of checking the interaction of drug Topamax (Topiramate Sprinkle Capsules) and disease Hemodialysis for safety when used together.

Check result:

Topamax (Topiramate Sprinkle Capsules) <> Hemodialysis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Topiramate is cleared by hemodialysis at a rate that is 4 to 6 times greater than that in a normal individual. A prolonged period of dialysis may cause plasma topiramate level to fall below that required to maintain an anti-seizure effect, thus a supplemental dose may be required in patients undergoing hemodialysis. The actual adjustment should take into account the duration of dialysis, the clearance rate of the dialysis system being used, and the effective renal clearance of topiramate in the patient being dialyzed.

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