Tolvaptan (Jynarque/Jinarc) and Renal impairment
Result of checking the interaction of drug Tolvaptan (Jynarque/Jinarc) and disease Renal impairment for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:There are no clinical trials of tolvaptan in patients with CrCl < 10 mL/min, and because drug effects on serum sodium levels are likely lost at very low levels of renal function, use in these patients is not recommended. Additionally, no benefit can be expected in anuric patients, so the use of tolvaptan is contraindicated in these patients.
Generic Name: tolvaptan
Brand Name: Samsca, Jynarque
Synonyms: Tolvaptan